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KMID : 0613820120220060852
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Journal of Life Science
2012 Volume.22 No. 6 p.852 ~ p.856
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In vivo Anti-inflammatory, Antipyretic, and Analgesic Activities of the Aquaculturable Green Seaweed Codium fragile Extracts in Mice
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Kang Ji-Young
Luyen Quoc-Hai
Khan Mohammed Nurul Absar
Choi In-Soon
Choi Jae-Suk
Hong Yong-Ki
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Abstract
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Dichloromethane, ethanol, and boiling water extracts of the green seaweed Codium fragile, used as an herbal medicine and known as an invasive species over the world, were examined for anti-inflammatory, antipyretic, and analgesic activities in mice. The dichloromethane and ethanol extracts inhibited inflammatory symptoms of mouse ear edema and erythema by 74% or higher. The extracts also demonstrated inhibition of pyrexia, similar to that of acetyl salicylic acid. Eicosapentaenoic acid was isolated from the seaweed as the main active anti-inflammatory compound. These findings are consistent with various claims that the seaweed can be used as remedies for inflammation-related symptoms.
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KEYWORD
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Codium fragile, anti-inflammation, eicosapentaenoic acid, indigenous medicine, green seaweed
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